|
T5175 |
Azd1390
|
|
ATM/ATR
|
|
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes. |
|
T3338 |
Ceralasertib
|
AZD6738 |
ATM/ATR
|
|
Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. |
|
T4443 |
AZ32
|
|
ATM/ATR
|
|
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. |
|
T1958 |
AZ20
|
|
ATM/ATR
,
mTOR
|
|
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR. |
|
T6770 |
AZD0156
|
|
Apoptosis
,
ATM/ATR
|
|
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing. |
|
T2685 |
KU-55933
|
ATM Kinase Inhibitor |
ATM/ATR
,
DNA-PK
,
PI3K
,
mTOR
,
Autophagy
|
|
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor. |
|
T1821 |
CGK733
|
CGK 733 |
ATM/ATR
|
|
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. |
|
T6261 |
CP-466722
|
CP 466722,CP466722 |
ATM/ATR
|
|
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells. |
|
T2084 |
ETP-46464
|
|
ATM/ATR
,
DNA-PK
,
PI3K
,
mTOR
|
|
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM). |
|
T3032 |
VE-821
|
ATR Inhibitor IV |
ATM/ATR
|
|
VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays). |
|
T6612 |
NU6027
|
|
ATM/ATR
,
DNA-PK
,
CDK
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. |
|
T7318 |
Elimusertib
|
BAY-1895344 |
ATM/ATR
|
|
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... |
|
T7122 |
AZD-7648
|
|
DNA-PK
|
|
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity. |
